Allele Frequency Calculator

Calculate gene variant frequencies in populations and test Hardy-Weinberg equilibrium

📊 Population Genotype Data

AA (Homozygous Dominant)

Aa (Heterozygous)

aa (Homozygous Recessive)

Dominant Alleles (A)

Recessive Alleles (a)

🧬 Hardy-Weinberg Principle

Equilibrium Equations

p + q = 1

Allele frequencies sum to 1

p² + 2pq + q² = 1

Genotype frequencies sum to 1

p = frequency of A, q = frequency of a

Where A is dominant and a is recessive allele

📈 Calculation Results

Dominant Allele (p) 0.500

Recessive Allele (q) 0.500

                                Total Population
                                1000
                            

                                Total Alleles
                                2000
                            

Allele Frequency Distribution

A: 50% a: 50%

Hardy-Weinberg Equilibrium Test

Expected AA 250

Expected Aa 500

Expected aa 250

                                    Chi-square
                                    0.000
                                

✓ Population is in Hardy-Weinberg Equilibrium

🧬 What is Allele Frequency?

Allele frequency is the relative frequency of an allele at a particular locus in a population, expressed as a fraction or percentage.

p = (2 × AA + Aa) / (2 × N)

Frequency of dominant allele A

q = (2 × aa + Aa) / (2 × N)

Frequency of recessive allele a

⚖️ Hardy-Weinberg Principle

The Hardy-Weinberg principle states that allele and genotype frequencies in a population will remain constant from generation to generation in the absence of evolutionary influences.

✓ No mutations
✓ Random mating
✓ No natural selection
✓ Large population size
✓ No gene flow

🔍 Applications in Genetics

Allele frequency calculations are essential for:

• Population genetics studies
• Evolutionary biology research
• Medical genetics and disease risk
• Conservation biology
• Forensic analysis
• Genetic counseling

Allele Frequency Calculator